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As for safety, the mid-stage trial found Ziihera to be well-tolerated, with only two patients discontinuing treatment due to toxicities
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The cAMP-PKA-STAT3 pathway is related to M2 differentiation, and there is another p-STAT1 protein whose phosphorylation is inhibited by GLP-1RAs, which is an M1 phenotype (Li et al., 2019)
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